| Product name | Lemairamin |
| Other name | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| CAS No. | 29946-61-0 |
| Molecular formula | C19H21NO3 |
| Molecular weight | 311.37 |
| Purity | 98.0% |
| Appearance | White to off-white powder |
| Application | Dietary Supplement Raw Material |
Lemairamin or Wgx50 is a natural compound derived from Sichuan pepper, which has shown promising effects in the prevention and treatment of Alzheimer's. It has been found to inhibit Aβ-induced neuronal apoptosis, reduce neuronal calcium toxicity, and decrease the accumulation of Aβ oligomers in the cerebral cortex. Additionally, wgx50 has been shown to improve the cognitive abilities of mice. Further investigation using atomic force microscopy (AFM) revealed that wgx50 can directly inhibit Aβ oligomers. Co-incubation of Aβ42 peptide with wgx50 prevented Aβ fibril growth, disassembled oligomers, and only a few fibrils remained. Molecular docking and MD simulations showed that wgx50 binds to hydrophobic grooves on the surface of Aβ protofibril and destabilizes the structure, disrupting the D23-K28 salt bridges, and partially opening the two tightly compacted β-sheets. This indicates that wgx50 has the potential to prevent the intermolecular protein-protein assembly of amyloid. Overall, the findings suggest that wgx50 has potential as a therapeutic agent for Alzheimer's and may provide a new avenue for the development of drugs that target Aβ oligomers. However, further studies are needed to investigate its efficacy and safety in humans.Wgx50 is currently in the research stage and its application status is mainly as a potential therapeutic agent for Alzheimer's. Wgx50 has shown promising results in preclinical studies, including inhibiting Aβ-induced neuronal apoptosis, reducing neuronal calcium toxicity, decreasing the accumulation of Aβ oligomers in the cerebral cortex, and improving the cognitive abilities of mice. The compound has also been shown to directly inhibit Aβ oligomers. The binding of wgx-50 on Aβ fibrils has been investigated by docking and MD simulations, revealing three possible stable binding sites. While further research is needed, the potential therapeutic benefits of wgx50 for AD are exciting and warrant continued investigation.
(1)Anti-inflammatory activity: WGX-50 exhibits significant anti-inflammatory activity, which makes it a promising candidate for treating inflammatory disorders. (2)Neuroprotective effects: WGX-50 has been shown to possess neuroprotective effects, protecting neurons from damage and preventing neurodegenerative diseases. (3)Anti-aging effect: WGX-50 has been found to have significant anti-aging effects on the skin, such as reducing wrinkles and improving skin elasticity. (4)Natural origin: WGX-50 is a natural compound extracted from Sichuan pepper, which makes it a safer and more sustainable alternative to synthetic compounds for various applications.
