| Product name | 7,8-Dihydroxyflavone |
| Other name | 7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4-benzopyrone; DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate; 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one |
| CAS No. | 38183-03-8 |
| Molecular formula | C15H10O4 |
| Molecular weight | 254.24 |
| Purity | 98.0% |
| Appearance | Yellow powder |
| Application | Dietary Supplement Raw Material |
(1) High purity: 7,8-Dihydroxyflavone preparation can obtain high-purity products through natural extraction and fine manufacturing process. High purity means better bioavailability and fewer adverse reactions. (2) Safety: 7,8-Dihydroxyflavone is a natural product that has been proven to be safe to humans. Within the dosage range, it has no toxicity or side effects. (3) Stability: 7,8-Dihydroxyflavone preparation has good stability and can maintain its activity and effect under different environmental and storage conditions. (4) Easy to absorb: 7,8-Dihydroxyflavone preparation can be quickly absorbed by the human body, enter the blood circulation through the intestinal tract, and distribute to different tissues and organs.7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring member of the flavonoid family. Studies have shown that 7,8-DHF can cross the blood-brain barrier, effectively mimic brain derived neurotrophin (BDNF), specifically bind to TrkB receptor, thus inducing dimerization and autophosphorylation of TrkB, and further activating MAPK/ERK, PI3K/Akt and PC downstream of the receptor γ Three signal pathways. At present, 7,8-DHF has been applied to the prevention and treatment of various BDNF/TrkB signaling related diseases, and has achieved a series of exciting results.
7, 8-DHF, as an effective small molecule activator of TrkB receptor, can play the role of neuron protection, neuron regeneration, synaptic plasticity regulation, etc. by simulating BDNF specific binding to TrkB and activating downstream signal pathways, so as to significantly improve the symptoms of emotional learning and spatial memory decline, cognitive ability decline, motor function decline and other symptoms of nervous system disease such as Alzheimer's disease or aging animal models, And alleviate the related phenotypes of mental illness and obese animals. Meanwhile, so far, no significant toxic side effects of 7,8-DHF have been found in experimental animals. 7,8-DHF has great potential and value in the prevention and treatment of BDNF/TrkB related issues.
